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pentobarbital will lower the extent or impact of estradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will minimize the extent or result of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.펜토바르비탈은 라이 증후군의 두개내의 압력